Synthesis and antibacterial activity of acrylpimaric acid and its thiadiazole derivatives

Acrylpimaric acid was prepared from rosin through Diels-Alder addition reaction, and then a series of thiadiazole derivatives from acrylpimaric acid were synthesized. Acrylpimaric Acid and its thiadiazole structures were characterized by IR, 1H NMR, MS, and elemental analysis. The antibacterial activities of these newly synthesized derivatives against Gram-negative bacteria and Gram-positive bacteria were also investigated. The results indicated that these compounds displayed extensive anti-bacterial activity against Gram-negative bacteria and gram-positive bacteria. Especially, compound 5f exhibited excellent antibacterial activity against Escherichia coli than bromogeramine. Compared with bromo-geramine (128 mg/L), compound 5f (64 mg/L) possessed a lower MIC value.