A fluorescence turn-on strategy to achieve detection of captopril based on Ag nanoclusters

被引：0

作者：

Xi L. ^{[1
]}

Zhang X. ^{[1
]}

Chen Y. ^{[1
]}

Peng J. ^{[4
]}

Liu M. ^{[1
]}

Huo D. ^{[1
]}

Li G. ^{[5
]}

He H. ^{[1
,2
,3
]}

机构：

[1] Department of Chemistry, China Pharmaceutical University, Nanjing

[2] Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing

[3] Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing

[4] College of Medical Engineering & the Key Laboratory for Medical Functional Nanomaterials, Jining Medical University, Jining

[5] College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing

来源：

Chemical Physics Letters | 2022年 / 807卷

关键词：

Ag nanoclusters; Captopril; Detection; Fluorescence;

D O I：

10.1016/j.cplett.2022.140085

中图分类号：

学科分类号：

摘要：

In this work, a fluorescence method based on a turn-on strategy to achieve detection of captopril was established utilizing Ag nanoclusters(AgNCs). Captopril as the second ligand can protect AgNCs through the Ag-S bond, promoting electron transfer on the surface of nanoclusters and enhancing the fluorescence intensity of AgNCs. Therefore, a sensitive method to detect captopril was achieved, which shown a good linear range from 5 to 60 μM with low limit of detection (1.12 μM). The proposed fluorescence detection system was applied in practical serum samples, indicating satisfying recovery and providing a simple and sensitive strategy for detection of captopril. © 2022 Elsevier B.V.

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