Diastereoselective Synthesis of Highly Functionalized γ-Lactams via Ugi Reaction/Michael Addition

被引：0
|
作者：
机构：
[1] Vidal, Herika D. A.
[2] Nunes, Paulo S. G.
[3] Martinez, Alice K. A.
[4] Januário, Marcelo A. P.
[5] Santiago, Pedro H. O.
[6] Ellena, Javier
[7] Corrêa, Arlene G.
来源：
Corrêa, Arlene G. (agcorrea@ufscar.br) | 2025年 / 20卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
Carbonyl compounds - Stereoselectivity;
D O I：
10.1002/asia.202400917
中图分类号：
学科分类号：
摘要：
The γ-lactam ring is a prominent feature in medicinal chemistry, and its synthesis has garnered significant interest due to its valuable properties. Among the γ-lactams, 2-oxopyrrolidine-3-carbonitrile derivatives stand out as versatile synthons that can be readily transformed into a variety of other functional groups. In this work, we successfully synthesized highly functionalized 3-cyano-2-pyrrolidinones with moderate to good overall yields using the Ugi reaction followed by intramolecular Michael addition. The process demonstrated excellent diastereoselectivity and showed good tolerance to a range of isonitriles and carbonyl compounds. © 2024 Wiley-VCH GmbH.
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