Tailor-made curdlan based nanofibrous dressings enable diabetic wound healing

被引:0
|
作者
Chen, Yang [1 ,2 ]
Bera, Hriday [3 ]
Si, Liangwei [1 ,2 ]
Xiu, Fangfang [1 ,2 ]
Liu, Peixin [1 ,2 ]
Li, Jiahui [1 ,2 ]
Xu, Xueying [1 ,2 ]
Zhu, Xiaoxuan [1 ,2 ]
Li, Yuxin [1 ,2 ]
Cun, Dongmei [1 ,2 ]
Guo, Xiong [1 ,2 ,4 ]
Yang, Mingshi [1 ,2 ,5 ]
机构
[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Wenhua Rd 103, Shenyang 110016, Peoples R China
[2] Minist Educ, Joint Int Res Lab Intelligent Drug Delivery Syst, Shenyang, Peoples R China
[3] Dr BC Roy Coll Pharm & Allied Hlth Sci, Durgapur 713206, India
[4] Shenyang Pharmaceut Univ, Sch Med Devices, Dept Biomed Engn, 103 Wenhua Rd, Shenyang 110016, Peoples R China
[5] Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, Denmark
关键词
Functionalized curdlan; Nanofiber dressings; Diabetic wounds; Macrophage phenotypes; NANOPARTICLES; REGENERATION; MACROPHAGES; HYDROGELS; RELEASE;
D O I
10.1016/j.carbpol.2024.122876
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The development and application of novel polysaccharides that can improve diabetic wound healing is crucial. Dressings containing curdlan have the potential to promote healing in diabetic wounds, but the underlying mechanism remain unclear. In addition, the functional modifications that could further enhance the activity of curdlan in promoting diabetic wound healing have not been explored. Herein, we investigated the capabilities of curdlan (CU) and its four derivatives i.e., sulfated curdlan (SC), amino-curdlan (AC) carboxymethyl curdlan (CMC) and CMC/ZnO nanocomposites for diabetic wound healing. Pristine CU and its derivatives were blended with polyvinyl alcohol (PVA) to fabricate electrospun nanofiber dressings (ENDs) with uniform appearances. The PVA/CU, PVA/CMC and PVA/CMC-ZnO ENDs were more compatible with keratinocytes, fibroblasts, and macrophages than that of PVA/AC ENDs. Notably, PVA/CMC ENDs and PVA/CMC-ZnO ENDs exhibited superior wound healing efficiencies than other ENDs. Among various dressings, PVA/CU, PVA/SC, PVA/CMC ENDs effectively reduced M1 macrophages and facilitated M2 phenotype at early stage of diabetic wound healing. Collectively, the PVA/CMC ENDs demonstrated greater therapeutic potential against diabetic wounds compared to other modified scaffolds via regulating macrophage polarization.
引用
收藏
页数:15
相关论文
共 50 条
  • [41] Electrospinning: An emerging technology to construct polymer-based nanofibrous scaffolds for diabetic wound healing
    Atta ur Rehman KHAN
    Yosry MORSI
    Tonghe ZHU
    Aftab AHMAD
    Xianrui XIE
    Fan YU
    Xiumei MO
    Frontiers of Materials Science, 2021, (01) : 10 - 35
  • [42] Process intensification by model-based design of tailor-made reactors
    Freund, Hannsjoerg
    Maussner, Johannes
    Kaiser, Markus
    Xie, Mingquan
    CURRENT OPINION IN CHEMICAL ENGINEERING, 2019, 26 : 46 - 57
  • [43] Tailor-made functional surfaces based on cellulose-derived materials
    Wang, Chao
    Venditti, Richard A.
    Zhang, Kai
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015, 99 (14) : 5791 - 5799
  • [44] Tailor-made functional surfaces based on cellulose-derived materials
    Chao Wang
    Richard A. Venditti
    Kai Zhang
    Applied Microbiology and Biotechnology, 2015, 99 : 5791 - 5799
  • [45] A tailor-made nucleoside-based colourimetric probe of formic acid
    Vanegas, Julie P.
    Zaballos-Garcia, Elena
    Perez-Prieto, Julia
    CHEMICAL COMMUNICATIONS, 2014, 50 (77) : 11335 - 11338
  • [46] Electrospinning: An emerging technology to construct polymer-based nanofibrous scaffolds for diabetic wound healing
    Atta ur Rehman Khan
    Yosry Morsi
    Tonghe Zhu
    Aftab Ahmad
    Xianrui Xie
    Fan Yu
    Xiumei Mo
    Frontiers of Materials Science, 2021, 15 : 10 - 35
  • [47] Electrospinning: An emerging technology to construct polymer-based nanofibrous scaffolds for diabetic wound healing
    Khan, Atta ur Rehman
    Morsi, Yosry
    Zhu, Tonghe
    Ahmad, Aftab
    Xie, Xianrui
    Yu, Fan
    Mo, Xiumei
    FRONTIERS OF MATERIALS SCIENCE, 2021, 15 (01) : 10 - 35
  • [48] A Study on Tailor-Made Speech Synthesis Based on Deep Neural Networks
    Yamada, Shuhei
    Nose, Takashi
    Ito, Akinori
    ADVANCES IN INTELLIGENT INFORMATION HIDING AND MULTIMEDIA SIGNAL PROCESSING, VOL 1, 2017, 63 : 159 - 166
  • [49] Zeolite-Loaded Hydrogels as Wound pH-Modulating Dressings for Diabetic Wound Healing
    Tricou, Leo-Paul
    Guirguis, Natalie
    Cherifi, Katia
    Matoori, Simon
    ACS APPLIED BIO MATERIALS, 2024, : 8102 - 8106
  • [50] Starch based nanofibrous scaffolds for wound healing applications
    Waghmare, Vijaya Sadashiv
    Wadke, Pallavi Ravindra
    Dyawanapelly, Sathish
    Deshpande, Aparna
    Jain, Ratnesh
    Dandekar, Prajakta
    BIOACTIVE MATERIALS, 2018, 3 (03) : 255 - 266