Maternal n-3 fatty acid supplementation has an immediate impact on the human milk fatty acid composition

被引：0

作者：

He, Yannan ^{[1
]}

Chen, Lin ^{[2
]}

Miao, Miao ^{[3
]}

Dai, Yongmei ^{[3
]}

Qin, Li ^{[4
]}

Lin, Jing ^{[5
]}

Qi, Yumei ^{[6
]}

Xiao, Huijuan ^{[6
]}

Qiu, Yajun ^{[7
]}

Zhang, Xiaohong ^{[8
]}

Sun, Hailan ^{[9
]}

Wang, Jianing ^{[9
]}

Xu, Meng-Yan ^{[10
]}

Tan, Ping ^{[11
]}

Yang, Bo ^{[12
]}

Sun, Guiju ^{[2
]}

Zhao, Feng ^{[1
]}

Li, Duo ^{[1
]}

机构：

[1] Institute of Nutrition & Health, Qingdao University, 308 Ningxia Road, Qingdao,266071, China

[2] School of Public Health, Southeast University, 87 Dingjiaqiao, Nanjing,210009, China

[3] Department of Nutrition, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, 123 MoChou Road, Nanjing,210004, China

[4] The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, 88 Jinlong Road, Hubei, Enshi,445000, China

[5] Department of Clinical Nutrition, Affiliated Hospital of Inner Mongolia Medical College, No. 1 North Road, Hui Min District, Huhhot, China

[6] Tianjin Third Central Hospital, 83 Jintang Road, Hedong District, Tianjin,300170, China

[7] Affiliated Hospital of Ningbo University Medical College, No. 247 Renmin Road, Jiangbei District, Ningbo,315211, China

[8] Department of Preventive Medicine, Health Science Center, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Zhejiang, Ningbo,315211, China

[9] The Department of Clinical Nutrition, Women and Children's Hospital of Chongqing Medical University, No. 120 Longshan Road, Chongqing,401120, China

[10] Department of nursing, Hangzhou Women's Hospital, No. 369 Kunpeng Rd., Shangcheng District, Zhejiang Province, Hangzhou,310008, China

[11] Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, No 16 Jiangsu Road, Qingdao,266000, China

[12] Institute of Lipids Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, China

来源：

Food and Function | 2024年 / 15卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Background. Fatty acids are essential components in breast milk with mutable characteristics. The fatty acid profiles of breast milk varied with lactating women's intake of long-chain polyunsaturated fatty acids (LCPUFAs) including DHA; EPA; and ALA. Objective. This study aimed to investigate the correlation between dietary n-3 PUFA supplementation and the hourly variation of the fatty acid compositions in breast milk. Materials and methods. The fatty acid profiles were analyzed in 600 human milk samples from 8 hospitals in 8 different Chinese areas. Blood and breast milk samples were obtained from a group of seventy-five lactating mothers; all within 6 to 9 months postpartum. Each mother collected 8 dried milk samples (DMSs) within 2 days: half an hour before breakfast; 2 and 3 hours after breakfast every day; and 2 and 3 hours after lunch on day 1. One fingertip blood sample was collected 10 minutes before the breakfast on the first day. The mothers took supplements containing about 3 grams of n-3 PUFAs at 10 minutes before the breakfast on day 2. Results. (1) In breast milk; oleic acid (C18:1n9c; OA) was the most abundant fatty acid (35.55%) followed by C18:2n6c (linoleic acid; LA; 24.45%); (2) the breast milk DHA of the inland participants (0.26%) was lower than that from coastal participants (0.57%); but compensated with much higher ALA (inland 3.19% vs. coastal 2.21%); and thus provided higher total milk n-3 PUFAs (inland 3.88% vs. coastal 3.28%); (3) the breast milk EPA and DHA increased from the baseline (EPA 0.17% and DHA 0.44%) after supplementation in 2 hours (EPA 0.18% and DHA 0.44%) and 3 hours (EPA 0.19% and DHA 0.46%). Conclusions. Dietary supplementation of n-3 PUFAs had an immediate impact on the breast milk fatty acid composition. The concentration of ALA; LA and OA was strengthened in breast milk compared to that in maternal blood. © 2024 The Royal Society of Chemistry;

D O I：

10.1039/d4fo02548b

中图分类号：

学科分类号：

摘要：

引用

页码：11630 / 11639

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