Effect of Gamma Irradiation Dose on Papain Toxicity

被引：0

作者：

Allayarova, U. Yu. ^{[1
]}

Demidov, S. V. ^{[1
]}

Blokhina, S. V. ^{[1
]}

Raevskaya, T. A. ^{[1
]}

Mishchenko, D. V. ^{[1
]}

Omel'chuk, Yu. A. ^{[2
]}

Allayarov, S. R. ^{[1
]}

机构：

[1] Russian Acad Sci, Fed Res Ctr Problems Chem Phys & Med Chem, Chernogolovka 142432, Moscow, Russia

[2] Sevastopol State Univ, Inst Nucl Energy & Ind, Sevastopol 299015, Russia

来源：

HIGH ENERGY CHEMISTRY | 2024年 / 58卷 / 05期

关键词：

papain; gamma-irradiation; aqueous dispersion; acute toxicity;

D O I：

10.1134/S0018143924700395

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The effect of a wide range of gamma-radiation dose from 250 to 3000 kGy on the acute toxicity of papain administered to laboratory animals has been studied. It has been discovered that preliminary gamma-irradiation of papain up to 1000 kGy reduces by more than five times the toxicity of its aqueous dispersions in the case of intraperitoneal administration. A further increase in the radiation dose to 3000 kGy does not lead to a noticeable change in the toxic effect. The study results indicate that gamma-irradiation of papain may be used to reduce its toxicity.

引用

页码：568 / 574

页数：7

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