Effect of Gamma Irradiation Dose on Papain Toxicity

被引：0
|
作者：
Allayarova, U. Yu. [1 ]
Demidov, S. V. [1 ]
Blokhina, S. V. [1 ]
Raevskaya, T. A. [1 ]
Mishchenko, D. V. [1 ]
Omel'chuk, Yu. A. [2 ]
Allayarov, S. R. [1 ]
机构：
[1] Russian Acad Sci, Fed Res Ctr Problems Chem Phys & Med Chem, Chernogolovka 142432, Moscow, Russia
[2] Sevastopol State Univ, Inst Nucl Energy & Ind, Sevastopol 299015, Russia
来源：
HIGH ENERGY CHEMISTRY | 2024年 / 58卷 / 05期
关键词：
papain; gamma-irradiation; aqueous dispersion; acute toxicity;
D O I：
10.1134/S0018143924700395
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The effect of a wide range of gamma-radiation dose from 250 to 3000 kGy on the acute toxicity of papain administered to laboratory animals has been studied. It has been discovered that preliminary gamma-irradiation of papain up to 1000 kGy reduces by more than five times the toxicity of its aqueous dispersions in the case of intraperitoneal administration. A further increase in the radiation dose to 3000 kGy does not lead to a noticeable change in the toxic effect. The study results indicate that gamma-irradiation of papain may be used to reduce its toxicity.
引用
收藏
页码：568 / 574
页数：7
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