New electrophiles targeting thiols in a reversible covalent manner

被引：0

作者：

Ma, Xingyu ^{[1
,2
]}

Xu, Manyi ^{[1
,2
]}

Wang, Fengge ^{[1
,2
]}

Hu, Tingting ^{[1
,2
]}

Chen, Xinyuan ^{[1
,2
]}

Zhang, Chong-Jing ^{[1
,2
]}

机构：

[1] Peking Union Med Coll & Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll & Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Act Subst Discovery & Druggabil Ev, Beijing 100050, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 85期

基金：

中国国家自然科学基金;

关键词：

RATIONAL DESIGN; INHIBITOR; CYSTEINES;

D O I：

10.1039/d4cc04612a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reversible covalent electrophiles with the advantages of both reversible and covalent interactions receive much attention in the fields of chemical biology and medicinal chemistry. Here, we report two electron-deficient olefins activated by amide and ester, amide-substituted acrylamide and methyl ester-substituted acrylamide, targeting thiols in a reversible covalent manner. Two electron-deficient olefins activated by amide and ester, amide-substituted acrylamide and methyl ester-substituted acrylamide, targeting thiols in a reversible covalent manner were reported.

引用

页码：12437 / 12440

页数：4

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