Reversal of Solvatochromism: A New Strategy to Construct Activatable Two-photon Fluorescent Probes for Sensing

被引：0
|
作者：
Zheng, Yingxin [1 ]
Zhang, Xing-Xing [1 ]
Shi, Ling [1 ]
Ren, Tian-Bing [1 ]
Yuan, Lin [1 ]
Zhang, Xiao-Bing [1 ]
机构：
[1] State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha,410082, China
来源：
Chemistry - An Asian Journal | 2022年 / 17卷 / 01期
关键词：
Charge transfer - Probes - Fluorescence - Photons;
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摘要：
Two-photon (TP) imaging with a donor-acceptor (D−A) type fluorophore is an emerging tool for bioimaging and sensing. However, current TP probes suffer from serious solvatochromic quenching in aqueous solution due to their strong intramolecular charge transfer (ICT) in excited states. In this work, based on solvatochromism reversal, we report a novel strategy to develop TP probes for bioimaging. Specifically, compared with the normal two-photon probes that showed a fluorescence off with ICT suppressed, the novel probes exhibited strong fluorescence in the aqueous solution when their ICT was inhibited. This strategy not only provides a new way for the design of high-performance TP probes, but also expands the biological analysis toolbox for use in living systems. © 2021 Wiley-VCH GmbH
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