Biological significance and pathophysiological role of Matrix Metalloproteinases in the Central Nervous System

被引：0

作者：

Ganguly, Krishnendu ^{[1
]}

Adhikary, Krishnendu ^{[1
]}

Acharjee, Arup ^{[2
]}

Acharjee, Papia ^{[3
]}

Trigun, Surendra Kumar ^{[3
]}

Mutlaq, Alaa Saeed ^{[4
]}

Ashique, Sumel ^{[5
,6
]}

Yasmin, Sabina ^{[7
]}

Alshahrani, Asma M. ^{[8
,9
]}

Ansari, Mohammad Yousuf ^{[10
]}

机构：

[1] Department of Medical Lab Technology, Paramedical College Durgapur, Helen Keller Sarani, West Bengal, Durgapur,713212, India

[2] Molecular Omics Laboratory, Department of Zoology, University of Allahabad, Uttar Pradesh, Allahabad, India

[3] Biochemistry Section, Department of Zoology, Banaras Hindu University, Uttar Pradesh, Varanasi,221005, India

[4] Deputy of Therapeutic, Saudi Ministry of Health, Saudi Arabia

[5] School of Pharmaceutical Sciences, Lovely Professional University, Punjab, Phagwara,144411, India

[6] Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences & Research, West Bengal, Durgapur,713212, India

[7] Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha,62529, Saudi Arabia

[8] Department of Clinical Pharmacy, Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia

[9] Department of Clinical Pharmacy, Shaqra University, Saudi Arabia

[10] MM college of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, Ambala,133207, India

来源：

International Journal of Biological Macromolecules | 2024年 / 280卷

关键词：

Matrix Metalloproteinases (MMPs); which are endopeptidase reliant on zinc; are low in embryonic tissues but increases in response to a variety of physiological stimulus and pathological stresses. Neuro-glial cells; endothelial cells; fibroblasts; and leucocytes secrete MMPs; which cleave extracellular matrix proteins in a time-dependent manner. MMPs affect synaptic plasticity and the development of short-term memory by controlling the size; shape; and excitatory synapses' function through the lateral diffusion of receptors. In addition; MMPs influence the Extracellular Matrix proteins in the Peri-Neuronal Net at the Neuro-glial interface; which aids in the establishment of long-term memory. Through modulating neuronal; and glial cells migration; differentiation; Neurogenesis; and survival; MMPs impact brain development in mammals. In adult brains; MMPs play a beneficial role in physiological plasticity; which includes learning; memory consolidation; social interaction; and complex behaviors; by proteolytically altering a wide variety of factors; including growth factors; cytokines; receptors; DNA repair enzymes; and matrix proteins. Additionally; stress; depression; addiction; hepatic encephalopathy; and stroke may all have negative effects on MMPs. In addition to their role in glioblastoma development; MMPs influence neurological diseases such as epilepsy; schizophrenia; autism spectrum disorder; brain damage; pain; neurodegeneration; and Alzheimer's and Parkinson's. To help shed light on the potential of MMPs as a therapeutic target for neurodegenerative diseases; this review summarizes their regulation; mode of action; and participation in brain physiological plasticity and pathological damage. Finally; by employing different MMP-based nanotools and inhibitors; MMPs may also be utilized to map the anatomical and functional connectome of the brain; analyze its secretome; and treat neurodegenerative illnesses. © 2024 Elsevier B.V;

D O I：

10.1016/j.ijbiomac.2024.135967

中图分类号：

学科分类号：

摘要：

引用

下载

共 50 条

[41] PATHOPHYSIOLOGICAL ALTERATIONS IN THE CENTRAL-NERVOUS-SYSTEM DUE TO TRAUMA
BULLOCK, R
SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT, 1993, 123 (11) : 449 - 458
[42] Vasoparalysis of the central nervous system, a characteristic vascular syndrome - Significance in the pathology of the central nervous system
Scheinker, M
ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 1944, 52 (01): : 43 - 56
[43] Biogenesis and Significance of Central Nervous System Myelin
Soldan, M. Mateo Paz
Pirko, Istvan
SEMINARS IN NEUROLOGY, 2012, 32 (01) : 9 - 14
[44] Microglia: Activation and their significance in the central nervous system
Nakajima, K
Kohsaka, S
JOURNAL OF BIOCHEMISTRY, 2001, 130 (02): : 169 - 175
[45] SIGNIFICANCE OF STOMACH TO CENTRAL NERVOUS SYSTEM IN PIGS
PETRI, S
PETRI, C
ACTA MEDICA SCANDINAVICA, 1969, 185 (05): : 453 - +
[46] REGULATION AND FUNCTION OF MATRIX METALLOPROTEINASES IN NERVOUS SYSTEM INJURY AND NEUROPATHIC PAIN
Pearce, Shane M.
Ramsey, Melissa A.
Miranpuri, Gurwattan S.
Resnick, Daniel K.
ANNALS OF NEUROSCIENCES, 2008, 15 (04) : 94 - 105
[47] Recent behavioral findings of pathophysiological involvement of lactate in the central nervous system
Kambe, Yuki
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2022, 1866 (07):
[48] Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders
Streck, Emilio L.
Goncalves, Cinara L.
Furlanetto, Camila B.
Scaini, Giselli
Dal-Pizzol, Felipe
Quevedo, Joao
REVISTA BRASILEIRA DE PSIQUIATRIA, 2014, 36 (02) : 156 - 167
[49] The biological resolution of malformations of the central nervous system
McLone, DG
NEUROSURGERY, 1998, 43 (06) : 1375 - 1380
[50] The Role of Calcium in the Central Nervous System
Arslan, Gokhan
ACTA PHYSIOLOGICA, 2019, 227 : 11 - 11

← 1 2 3 4 5 →