Biological significance and pathophysiological role of Matrix Metalloproteinases in the Central Nervous System

被引：0

作者：

Ganguly, Krishnendu ^{[1
]}

Adhikary, Krishnendu ^{[1
]}

Acharjee, Arup ^{[2
]}

Acharjee, Papia ^{[3
]}

Trigun, Surendra Kumar ^{[3
]}

Mutlaq, Alaa Saeed ^{[4
]}

Ashique, Sumel ^{[5
,6
]}

Yasmin, Sabina ^{[7
]}

Alshahrani, Asma M. ^{[8
,9
]}

Ansari, Mohammad Yousuf ^{[10
]}

机构：

[1] Department of Medical Lab Technology, Paramedical College Durgapur, Helen Keller Sarani, West Bengal, Durgapur,713212, India

[2] Molecular Omics Laboratory, Department of Zoology, University of Allahabad, Uttar Pradesh, Allahabad, India

[3] Biochemistry Section, Department of Zoology, Banaras Hindu University, Uttar Pradesh, Varanasi,221005, India

[4] Deputy of Therapeutic, Saudi Ministry of Health, Saudi Arabia

[5] School of Pharmaceutical Sciences, Lovely Professional University, Punjab, Phagwara,144411, India

[6] Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences & Research, West Bengal, Durgapur,713212, India

[7] Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha,62529, Saudi Arabia

[8] Department of Clinical Pharmacy, Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia

[9] Department of Clinical Pharmacy, Shaqra University, Saudi Arabia

[10] MM college of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, Ambala,133207, India

来源：

International Journal of Biological Macromolecules | 2024年 / 280卷

关键词：

Matrix Metalloproteinases (MMPs); which are endopeptidase reliant on zinc; are low in embryonic tissues but increases in response to a variety of physiological stimulus and pathological stresses. Neuro-glial cells; endothelial cells; fibroblasts; and leucocytes secrete MMPs; which cleave extracellular matrix proteins in a time-dependent manner. MMPs affect synaptic plasticity and the development of short-term memory by controlling the size; shape; and excitatory synapses' function through the lateral diffusion of receptors. In addition; MMPs influence the Extracellular Matrix proteins in the Peri-Neuronal Net at the Neuro-glial interface; which aids in the establishment of long-term memory. Through modulating neuronal; and glial cells migration; differentiation; Neurogenesis; and survival; MMPs impact brain development in mammals. In adult brains; MMPs play a beneficial role in physiological plasticity; which includes learning; memory consolidation; social interaction; and complex behaviors; by proteolytically altering a wide variety of factors; including growth factors; cytokines; receptors; DNA repair enzymes; and matrix proteins. Additionally; stress; depression; addiction; hepatic encephalopathy; and stroke may all have negative effects on MMPs. In addition to their role in glioblastoma development; MMPs influence neurological diseases such as epilepsy; schizophrenia; autism spectrum disorder; brain damage; pain; neurodegeneration; and Alzheimer's and Parkinson's. To help shed light on the potential of MMPs as a therapeutic target for neurodegenerative diseases; this review summarizes their regulation; mode of action; and participation in brain physiological plasticity and pathological damage. Finally; by employing different MMP-based nanotools and inhibitors; MMPs may also be utilized to map the anatomical and functional connectome of the brain; analyze its secretome; and treat neurodegenerative illnesses. © 2024 Elsevier B.V;

D O I：

10.1016/j.ijbiomac.2024.135967

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