Synthesis and structural confirmation of selaginpulvilin X

被引：0

作者：

Havlikova, Tereza ^{[1
]}

Nallappan, Sundaravelu ^{[1
]}

Cisarova, Ivana ^{[2
]}

Rycek, Lukas ^{[1
]}

机构：

[1] Charles Univ Prague, Fac Sci, Dept Organ Chem, Hlavova 8, Prague 12800, Czech Republic

[2] Charles Univ Prague, Fac Sci, Dept Inorgan Chem, Hlavova 8, Prague 12800, Czech Republic

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 45期

关键词：

SELAGINELLA-TAMARISCINA; INHIBITORS; PATHWAY;

D O I：

10.1039/d4ob01529k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the first total synthesis of the natural product selaginpulvilin X, a selaginellaceae polyphenol class of compounds. Our synthetic strategy employs cross-coupling reactions and an organolithium addition to construct the carbon framework. Subsequently, the functional group modifications and deprotection yield the natural product. Spectral analysis confirms the proposed structure by comparing natural and synthetic samples. We report the first synthesis of natural product selgunpulvilin X, isolated recently from selaginalla pulvinata.

引用

页码：8843 / 8846

页数：4

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