Synthesis of pH-Sensitive and Self-Fluorescent Polymeric Micelles Derived From Rosin and Vegetable Oils via ATRP

被引:0
|
作者
Yu, Juan [1 ,2 ]
Xu, Chaoqun [1 ]
Lu, Chuanwei [1 ,2 ]
Liu, Qian [3 ]
Wang, Jifu [2 ]
Chu, Fuxiang [1 ,2 ]
机构
[1] Key Laboratory of Forestry Genetics and Biotechnology, Jiangsu Province Key Laboratory of Green Biomass-based Fuels and Chemicals, Ministry of Education, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of C
[2] National Engineering Laboratory of Biomass Chemical Utilization, Key and Laboratory of Forest Chemical Engineering, SFA, Key Laboratory of Biomass Energy and Material, Institute of Chemical Industry of Forest Products, CAF, Nanjing, China
[3] Research Center for Nanophotonic and Nanoelectronic Materials, School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou, China
来源
Frontiers in Bioengineering and Biotechnology | 2021年 / 9卷
基金
中国国家自然科学基金;
关键词
Atom-transfer radical polymerization - Dehydroabietic acid - Doxorubicin - Lauryl methacrylate - pH sensitive - Polymeric micelle - Polymethacrylic acid - Rosin - Self-fluorescence - Sustainable polymers;
D O I
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中图分类号
学科分类号
摘要
Preparation and application of sustainable polymers derived from renewable resources are of great significance. The aim of this study is to synthesize a kind of sustainable polymeric micelles from rosin and vegetable oils via atom transfer radical polymerization (ATRP) and to investigate the doxorubicin delivery properties of these micelles. Dehydroabietic acid–based poly lauryl methacrylate (DA-PLMA) with narrow PDI of 1.13 was prepared in a well-controlled process using rosin as an ATRP initiator. Thereafter, carboxylic groups were introduced to form poly methacrylic acid (PMAA) moieties in DA-PLMA polymer via acid hydrolysis. The resulted DA-PLMA-PMAA could self-assemble in water to form pH-dependent polymeric micelles with a diameter of ∼65 nm and PDI as low as 0.105. Owing to the existence of rosin, DA-PLMA-PMAA micelles also showed self-fluorescence properties. In addition, Dox-loaded micelles were prepared in aqueous solution with the drug-loading capacity as high as 16.0% and showed sustained-release characteristics. These results demonstrate great promise for designing polymeric micellar from rosin and vegetable oils. © Copyright © 2021 Yu, Xu, Lu, Liu, Wang and Chu.
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