Design and synthesis of novel quinazolinone-based pyruvate kinase M2 activators as selective inhibitors of oral cancer cells

被引：0
|
作者：
Rathod, Bhagyashri [1 ]
Joshi, Swarali [2 ]
Regu, Siddulu [1 ]
Manikanta, K.V.N.S. [2 ]
Kumar, Hansal [1 ]
Dubey, Samdisha [2 ]
Chowdhury, Arnab [1 ]
Shaikh, Raisa Parveen [2 ]
Das, Anwesha [1 ]
Patel, Sagarkumar [1 ]
Satvase, Rutuja [2 ]
Chatterjee, Deep Rohan [1 ]
Jain, Alok [2 ]
Garg, Rachana [2 ]
Shard, Amit [1 ]
机构：
[1] Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research- Ahmedabad, Gujarat, Gandhinagar,382355, India
[2] Department of Biotechnology, National Institute of Pharmaceutical Education and Research- Ahmedabad, Gujarat, Gandhinagar,382355, India
来源：
Journal of Molecular Structure | 2024年 / 1304卷
关键词：
Cells; -; Cytology; Diseases; Enzymes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Design and synthesis of novel quinazolinone-based pyruvate kinase M2 activators as selective inhibitors of oral cancer cells
    Rathod, Bhagyashri
    Joshi, Swarali
    Regu, Siddulu
    Manikanta, K. V. N. S.
    Kumar, Hansal
    Dubey, Samdisha
    Chowdhury, Arnab
    Shaikh, Raisa Parveen
    Das, Anwesha
    Patel, Sagarkumar
    Satvase, Rutuja
    Chatterjee, Deep Rohan
    Jain, Alok
    Garg, Rachana
    Shard, Amit
    JOURNAL OF MOLECULAR STRUCTURE, 2024, 1304
  • [2] Design, synthesis and biological activity of novel quinazolinone-based Caspase 3 inhibitors
    Greenfield, A
    Grosanu, C
    Tawa, GJ
    Childers, WE
    Harrison, BL
    Magolda, RL
    Robichaud, AJ
    Aulabaugh, A
    Chan, H
    Cowling, R
    Fennel, M
    Huang, XY
    Hum, WT
    Kapoor, B
    Ling, HP
    Wood, A
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U2684 - U2684
  • [3] Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity
    Sonousi, Amr
    Hassan, Rasha A.
    Osman, Eman O.
    Abdou, Amr M.
    Emam, Soha H.
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 37 (01) : 2644 - 2659
  • [4] The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells
    Kurihara-Shimomura, Miyako
    Sasahira, Tomonori
    Nakashima, Chie
    Kuniyasu, Hiroki
    Shimomura, Hiroyuki
    Kirita, Tadaaki
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (10)
  • [5] Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors
    Hsieh, I-Shan
    Gopula, Balraj
    Chou, Chi-Chi
    Wu, Hsiang-Yi
    Chang, Geen-Dong
    Wu, Wen-Jin
    Chang, Chih-Shiang
    Chu, Po-Chen
    Chen, Ching S.
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (18) : 8497 - 8510
  • [6] PYRUVATE KINASE M2 ACTIVATORS INHIBIT TUMOR GROWTH
    不详
    CANCER DISCOVERY, 2012, 2 (10) : 866 - 866
  • [7] Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents
    Rathod, Bhagyashri
    Chak, Shivam
    Patel, Sagarkumar
    Shard, Amit
    RSC MEDICINAL CHEMISTRY, 2021, 12 (07): : 1121 - 1141
  • [8] Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors
    Dimitrijevs, Pavels
    Makrecka-Kuka, Marina
    Bogucka, Agnieszka
    Hyvonen, Marko
    Pantelejevs, Teodors
    Arsenyan, Pavel
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 257
  • [9] Design and synthesis of novel quinazolinone-based fibrates as PPARα agonists with antihyperlipidemic activity
    Hassan, Rasha M.
    Ali, Islam H.
    Abdel-Maksoud, Mohammed S.
    Abdallah, Heba M. I.
    El Kerdawy, Ahmed M.
    Sciandra, Francesca
    Ghannam, Iman A. Y.
    ARCHIV DER PHARMAZIE, 2022, 355 (03)
  • [10] Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation
    Tran Khac Vu
    Nguyen Thi Thanh
    Nguyen Van Minh
    Nguyen Huong Linh
    Nguyen Thi Phuong Thao
    Truong Thuc Bao Nguyen
    Doan Thi Hien
    Luu Van Chinh
    Ta Hong Duc
    Lai Duc Anh
    Pham-The Hai
    MEDICINAL CHEMISTRY, 2021, 17 (07) : 732 - 749
12345