Photoredox catalyzed reductive trifluoromethylation of imines via a radical umpolung strategy

被引：0

作者：

Paul, Hrishikesh ^{[1
]}

Das, Dibyangshu ^{[1
]}

Ariyan, S.K. ^{[1
]}

Pradhan, Suman ^{[1
]}

Chatterjee, Indranil ^{[1
]}

机构：

[1] Department of Chemistry, Indian Institute of Technology Ropar, Nangal Road, Punjab, Rupnagar,140001, India

来源：

Chemical Communications | 2024年 / 60卷 / 89期

关键词：

Synthesis; (chemical);

D O I：

10.1039/d4cc03897e

中图分类号：

O6 [化学]; TQ03 [化学反应过程]; TQ02 [化工过程（物理过程及物理化学过程）];

学科分类号：

0703 ; 081701 ; 081704 ;

摘要：

Visible light-induced radical umpolung chemistry is utilized to synthesize trifluoromethylated unnatural α-amino acid and amine derivatives. This approach utilizes photoredox catalysis to perform a single-electron-transfer reduction of imines generating a N-centred radical that eventually migrates to the C-centre followed by a radical-radical cross-coupling to deliver reductive trifluoromethylation products. © 2024 The Royal Society of Chemistry.

引用

页码：13016 / 13019

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