Photoredox-Catalyzed Multicomponent Synthesis of Functionalized γ-Amino Butyric Acids via Reductive Radical Polar Crossover

Multicomponent radical polar crossover (RPC) reactions are useful for leveraging both radical and polar bond forming steps to rapidly build molecular complexity in a single transformation. However, multicomponent RPC reactions that utilize carbonyl pi-bond electrophiles are underrepresented in the literature. Herein, we describe a mild, photoredox-catalyzed decarboxylative multicomponent RPC reaction that couples carboxylic acids, Michael acceptors, and carbonyl electrophiles for the formation of diversely functionalized gamma-amino butyric acid derivatives. This transformation also facilitates the synthesis of complex and biologically relevant gamma-lactam compounds.