In recent years, flexible piezoresistive sensors have attracted tremendous attention due to their broad application prospects in individual motion and health monitoring. As a new two-dimensional material, MXene has excellent electrical conductivity and hydrophilicity, and is easy to com-pound with other functional materials. In particular, it is easy to produce micro / nano cracks during the press process due to its brittle structure, so it is considered as a promising candidate for the preparation of high sensitivity piezoresistive sensors. To achieve full-range monitoring of the hu-man body, the piezoresistive sensor needs to satisfy both large working range and high sensitivity. However, the rapid expansion of micro / nano cracks in MXene leads to the rapid destruction of its conductive path, resulting in a smaller working range. To solve this problem, many resear-chers have focused on the construction of micro / nano structures in recent years, trying to maintain the connectivity of the conductive path or slow down the micro / nano crack propagation while the sensing process, and simultaneously achieve the high sensitivity and wide operating range of MXene based sensors. In this paper, the preparation methods of MXene and the sensing mechanism of piezoresistive sensor were summarized. Then, the preparation strategies of flexible piezoresistive sensor based on MXene were reviewed from strain type and pressure type. Meanwhile, the application of MXene-based flexible piezoresistive sensor was summarized. Finally, the future development trend of MXene-based flexible pie-zoresistive sensor was prospected. It is expected to provide a reference for the preparation of piezoresistive sensor with large working range and high sensitivity. © 2022 Cailiao Daobaoshe/ Materials Review. All rights reserved.