Additively manufactured porous Ti6Al4V Alloy with excellent mechanical properties, corrosion resistance, in vitro and in vivo biocompatibility

被引：0

作者：

Zhang, Lei ^{[1
,2
,3
]}

Hu, Hongyan ^{[4
]}

Wang, Quan ^{[5
]}

Zhou, Jing ^{[6
]}

Liu, Yan ^{[5
]}

Li, Zonghao ^{[1
,3
]}

Zhang, Yonghui ^{[5
]}

Kui, Zhitong ^{[1
,3
]}

He, Zhengyuan ^{[1
,3
]}

Jiang, Yehua ^{[1
,3
]}

机构：

[1] School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming,650093, China

[2] China Nonferrous Metals Innovation Institute (Tianjin) Co, Ltd, Tianjing,300393, China

[3] National-Local Joint Engineering Research Center for Technology of Advanced Metallic Solidification Forming and Equipment, Kunming,650000, China

[4] Peking University Cancer Hospital Yunnan (Tumor Hospital of Yunnan Province), Kunming,650118, China

[5] Kunming Medical University School of Stomatology and Affiliated Stomatology Hospital, Kunming,650106, China

[6] Department of Stomatology, Kunming Yan'an Hospital, Kunming,650051, China

来源：

Journal of Alloys and Compounds | 2024年 / 1009卷

关键词：

In view of the insufficient bearing capacity of porous Ti6Al4V (TC4) alloy; four kinds of porous TC4 alloys with a wall thickness of 200 μm and a side length ranging from 400 to 700 μm were designed and subsequently prepared by Additive Manufacturing (Selective Laser Melting; SLM). The results indicated that the porous TC4 alloy was primarily comprised of α' phase and a small amount of β phase. As the side length increased; the size and volume of the acicular α' phase increased while the β phase decreased. Besides; the dislocation density also increased with the increase of side length. The porous TC4 alloy with a side length of 700 μm exhibited the maximum dislocation density of 6.07×1014 m2. The yield strength and elastic modulus initially decreased and then increased with the increase of side length. Moreover; the increase in side length induced the decrease of Icorr from 1.807 × 10−6 to 4.777 × 10−7 A/cm2; especially that sample 7–2 presented the best corrosion resistance with the smallest Icorr value (4.777 × 10−7 A/cm2). It was observed by in vitro assessment that the optical density (OD) of the porous TC4 alloys surpassed 75 % on days 1; 4; and 7. It was noteworthy that the OD value of the porous TC4 alloys with a side length of 700 μm surpassed 100 % on day 7. Furthermore; the number of adherent cells displayed an increasing trend with the increase in side length. After implanting into the alveolar bone of rabbits at 12th week; the porous TC4 alloy with a side length of 700 μm induced bone growth due to a higher percentage of bone volume compared to the dental implant. After 12 weeks of in vivo experiments; the results showed that the porous TC4 alloy could reduce the inflammatory response; promote the growth of bone tissue; and have excellent osteogenic properties. © 2024 Elsevier B.V;

D O I：

10.1016/j.jallcom.2024.176982

中图分类号：

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