The correlation between plasma levels in vivo and dissolution in vitro of ibuprofen sustained-release capsule

OBJECTIVE: To determine the plasma levels of ibuprofen after oral administration and to study the correlation between the absorption in vivo and the dissolution in vitro of ibuproten sustained-release capsule. METHODS: The plasma levels were determined by HPLC. The limearity was obtained over the range of 4.6-24.6 mg&middotmL-1. The dissolution was tested according to Vhinese Pharmacopoeia 1995 Appendices XC, using the first method. RESULTS: TSA linear regressive equation was established between the absorption percentage in vivo and the accumualte dissolution percentage in vitro of ibuprofen. F = 6. 2205x + 1. 0901 (r = 0.9755). CONCLUSION: There was a significant correlation between the dissolution in vitro and the absorption in vitro of ibuprofen sustained-release capsule.