The correlation between plasma levels in vivo and dissolution in vitro of ibuprofen sustained-release capsule

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作者：
Clinical Pharmacy Institute, Second Affi. Hosp. Harbin Med. Univ., Harbin 150086, China [1 ]
机构：
来源：
Chinese Pharmaceutical Journal | 2001年 / 36卷 / 06期
关键词：
Absorption - Correlation methods - Dissolution - High pressure liquid chromatography - Linear equations;
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摘要：
OBJECTIVE: To determine the plasma levels of ibuprofen after oral administration and to study the correlation between the absorption in vivo and the dissolution in vitro of ibuproten sustained-release capsule. METHODS: The plasma levels were determined by HPLC. The limearity was obtained over the range of 4.6-24.6 mg&middotmL-1. The dissolution was tested according to Vhinese Pharmacopoeia 1995 Appendices XC, using the first method. RESULTS: TSA linear regressive equation was established between the absorption percentage in vivo and the accumualte dissolution percentage in vitro of ibuprofen. F = 6. 2205x + 1. 0901 (r = 0.9755). CONCLUSION: There was a significant correlation between the dissolution in vitro and the absorption in vitro of ibuprofen sustained-release capsule.
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页码：397 / 399
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