Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women

被引：0
|
作者：
Chen, Jun [1 ]
Zhang, Li-Ping [1 ]
Qiu, Jun-Feng [1 ]
Peng, Hui [1 ]
Deng, Zhong-Liang [1 ]
Wang, Yu-Jun [1 ]
Yan, Zhong-De [1 ]
机构：
[1] Department of Endocrinology, Second Teaching Hospital, Chongqing Medical University, Chongqing 400010, China
来源：
Chinese Journal of Medical Genetics | 2003年 / 20卷 / 02期
关键词：
Genetic engineering - Patient monitoring - Vitamins;
D O I：
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学科分类号：
摘要：
Objective: To determine the relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis in postmenopausal women. Methods: The polymerase chain reaction-restriction fragment length polymorphism was used to detect VDR genotype in 40 patients with osteoporosis and 21 healthy postmenopausal women. Results: In the patients with osteoporosis, the bb, Bb, and BB genotype accounted for 82.5%, 17.5% and 0, respectively; in healthy groups, they were 85. 71%, 14.29% and 0, respectively (P>0.05). Conclusion: Significant association between VDR genotype and osteoporosis in Chinese women was observed in this study.
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页码：167 / 168
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