A continuous flow microreactor as a practical tool for the synthesis of active pharmaceutical ingredients

被引：0

作者：

Bhaskar, K. Vijaya ^{[1
]}

Rashed, Mohammad ^{[1
]}

Bhat, K. Subrahmanya ^{[2
]}

Lee, Jechan ^{[3
,4
]}

Kim, Ki-Hyun ^{[5
]}

Buruga, Kezia ^{[6
]}

机构：

[1] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut Chem, Manipal 576104, India

[2] Manipal Inst Technol, Manipal Acad Higher Educ, Dept Chem, Manipal 576104, India

[3] Sungkyunkwan Univ, Dept Global Smart City, Suwon 16419, South Korea

[4] Sungkyunkwan Univ, Sch Civil Architectural Engn & Landscape Architect, Suwon 16419, South Korea

[5] Hanyang Univ, Dept Civil & Environm Engn, Seoul 04763, South Korea

[6] Natl Inst Technol Karnataka, Dept Chem Engn, Surathkal 575025, India

来源：

PROCESS SAFETY AND ENVIRONMENTAL PROTECTION | 2024年 / 192卷

基金：

新加坡国家研究基金会;

关键词：

Microreactor; Lab-on-a-chip; Continuous flow system; Automation; APIs; ORGANIC-SYNTHESIS; MICROCHEMICAL SYSTEMS; INTEGRATED SYNTHESIS; SCALE-UP; CHEMISTRY; MICROFLUIDICS; TECHNOLOGY; REACTOR; DESIGN; LITHOGRAPHY;

D O I：

10.1016/j.psep.2024.09.122

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Continuous flow processing has become a key technology to maximize the capabilities of chemical syntheses. Numerous new tactics have been devised to synthesize various chemicals including active pharmaceutical ingredients (APIs) via a continuous flow system using microreactors. This review aims to illustrate the holistic system approach and diverse applications of continuous flow microreactors for the synthesis of APIs (with respect to type, design, and fabrication). This review also highlights the applicability of continuous flow microreactors in the synthesis of APIs in contrast to conventional batch-type methods along with a discussion of their merits and demerits. Overall, this review is expected to offer valuable insights into the utility of continuous flow microreactor technology for the upscaled production of commercially feasible APIs.

引用

页码：437 / 449

页数：13

共 50 条

[41] Prequalification of active pharmaceutical ingredients
WHO EXPERT COMMITTEE ON SPECIFICATIONS FOR PHARMACEUTICAL PREPARATIONS, 2015, 992 : 37 - 37
[42] Prequalification of active pharmaceutical ingredients
WHO EXPERT COMMITTEE ON SPECIFICATIONS FOR PHARMACEUTICAL PREPARATIONS, 2013, 981 : 29 - 29
[43] Multistep cascade continuous flow synthesis of AOS based on microreactor
Xu, Yiming
Li, Ping
Ma, Haoran
Huang, Ailing
Zhao, Wei
Zhao, Xi
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2023, 192
[44] Safe and Efficient Tetrazole Synthesis in a Continuous-Flow Microreactor
Palde, Prakash B.
Jamison, Timothy F.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (15) : 3525 - 3528
[45] Synthesis of copper nanocolloids using a continuous flow based microreactor
Xu, Lei
Peng, Jinhui
Srinivasakannan, C.
Chen, Guo
Shen, Amy Q.
APPLIED SURFACE SCIENCE, 2015, 355 : 1 - 6
[46] Continuous flow synthesis of pendimethalin in a microreactor for thermal risk reduction
Fu, Gang
Ma, Kai
Jiang, Juncheng
Ni, Lei
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES, 2025, 94
[47] Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability
Imbrogno, Joseph
Rogers, Luke
Thomas, Dale A.
Jensen, Klavs F.
CHEMICAL COMMUNICATIONS, 2018, 54 (01) : 70 - 73
[48] Convergent synthesis of polyamide dendrimer using a continuous flow microreactor
Liu, Shuhong
Chang, Chih-Hung
Paul, Brian K.
Remcho, Vincent T.
CHEMICAL ENGINEERING JOURNAL, 2008, 135 (S333-S337) : S333 - S337
[49] Synthesis of nickel nanoparticles by aqueous reduction in continuous flow microreactor
Xu, Lei
Srinivasakannan, C.
Peng, Jinhui
Zhang, Di
Chen, Guo
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2015, 93 : 44 - 49
[50] Continuous-flow synthesis of azo dyes in a microreactor system
Wang, Fajun
Huang, Jinpei
Xu, Jianhong
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2018, 127 : 43 - 49

← 1 2 3 4 5 →