RAFT controlled synthesis of graphene/polymer hydrogel with enhanced mechanical property for pH-controlled drug release

被引：0

作者：

Liu, Jingquan ^{[1
]}

Cui, Liang ^{[1
]}

Kong, Na ^{[1
]}

Barrow, Colin J. ^{[2
]}

Yang, Wenrong ^{[2
]}

机构：

[1] Chemical and Environmental Engineering, Laboratory of Fiber Materials and Modern Textile, Qingdao University, Qingdao 266071, China

[2] Center for Chemistry and Biotechnology, Deakin University, Geelong, VIC 3217, Australia

来源：

European Polymer Journal | 2014年 / 50卷 / 01期

关键词：

A pH-sensitive; mechanically strong and thermally stable graphene/poly (acrylic acid) (graphene/PAA) hydrogel was prepared via reversible addition fragmentation transfer (RAFT) polymerizations in the presence of a cross-linking agent. The RAFT agent was covalently coupled onto graphene basal planes via an esterification reaction; with benzoic acid functionalities pre-attached on graphene with its aryl diazonium salt precursor. AFM and SEM analysis revealed the successful preparation of single layered graphene sheets and graphene/polymer hydrogels with pH controlled porous structures. Attenuated total reflection infrared (ATR-IR) and thermogravimetric analyzer (TGA) verified the successful stepwise preparation of graphene/PAA hydrogel. This graphene/PAA hydrogel was pH-sensitive and more mechanically elastic than the PAA hydrogel prepared without graphene. The pH sensitivity of the hydrogel was further utilized for controlled drug release. Doxorubicin was chosen as a model drug and loaded into the hydrogels. The drug loading and release experiment indicated that this hydrogel can be used to efficiently control drug release in the intestine environment (pH = 7.4); better than release in a more acidic environment.© 2013 Elsevier Ltd. All rights reserved;

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摘要：

Journal article (JA)

引用

页码：9 / 17

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