The effect of lysophosphatidylcholine on the radiation-initiated lipid peroxidation in liposomes

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作者：
Kisel, M.A. [1 ]
Shadyro, O.I. [1 ]
Yurkova, I.L. [1 ]
机构：
[1] Inst. of Bioorganic Chemistry, NAS of Belarus, Minsk, 220131, Belarus
来源：
Radiatsionnaya Biologiya. Radioekologiya | 2001年 / 41卷 / 01期
关键词：
Animal cell culture - Biochemistry - Cell membranes - Gamma rays - Lipids - Oxidation - Peroxides;
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摘要：
The effect of lysophosphatidylcholine (LPC) on the lipid peroxidation process (LPO) in liposomes of rat liver phosphatidylcholine initiated by irradiation of 137Cs source was studied. The formation of diene conjugates (DC) is shown to increase dramatically on incorporation of more than 10% LPC into liposomes. The dependence of DC proportion on the irradiation dose is practically linear in the range of 0 to 5 kGy. The DC concentration in the liposomes without LPC grows at least to dose of 3.3 kGy and is unchanged on further irradiation. The malonic dialdehide accumulation follows the similar dependence. The LPC effect is neutralized by the incorporation of cholesterol into liposomes. The product of free radical fragmentation of LPC, palmitoxyacetone, practically has no influence on the DC concentration. The reasons of LPC effect on the irradiation initiated LPO in liposomes is discussed.
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页码：20 / 23
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