3D printed polycaprolactone/gelatin/ordered mesoporous calcium magnesium silicate nanocomposite scaffold for bone tissue regeneration

被引：0
|
作者：
Mirzavandi, Zahra [1 ]
Poursamar, Seyed Ali [1 ]
Amiri, Farshad [1 ]
Bigham, Ashkan [2 ,3 ]
Rafienia, Mohammad [1 ,4 ]
机构：
[1] Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
[2] Institute of Polymers, Composites, and Biomaterials, National Research Council, Naples, Italy
[3] Department of Chemical, Materials and Production Engineering, University of Naples Federico II, Naples, Italy
[4] Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
来源：
Journal of Materials Science: Materials in Medicine | 2024年 / 35卷 / 01期
关键词：
Tissue engineering scaffolds are three-dimensional structures that provide an appropriate environment for cellular attachment; proliferation; and differentiation. Depending on their specific purpose; these scaffolds must possess distinct features; including appropriate mechanical properties; porosity; desired degradation rate; and cell compatibility. This investigation aimed to fabricate a new nanocomposite scaffold using a 3D printing technique composed of poly(Ε-caprolactone) (PCL)/Gelatin (GEL)/ordered mesoporous calcium-magnesium silicate (om-CMS) particles. Different weight ratios of om-CMS were added and optimized; and a series of scaffolds were constructed for comparison purposes; including PCL 50%/Gel 50%; PCL; 50%/Gel; 45%/om-CMS%5; and PCL 50%/Gel 40%/om-CMS%10. The optimized weight ratio of om-CMS was 10% without leaving behind negative effects on the filaments’ structure. The scaffolds’ physical and chemical properties were assessed using various techniques; and their degradation rate; bioactivity potential; cell viability; attachment; and ALP activity were evaluated in vitro. The results demonstrated that the PCL 50%/Gel 40%/om-CMS10% scaffold had promising potential for further studies in bone tissue regeneration. Graphical Abstract: (Figure presented.). © The Author(s) 2024;
D O I：
10.1007/s10856-024-06828-5
中图分类号：
学科分类号：
摘要：
引用
下载
收藏
相关论文
共 50 条
  • [21] 3D Printed Integrated Bionic Oxygenated Scaffold for Bone Regeneration
    Wang, Yihan
    Xie, Changnan
    Zhang, Zhiming
    Liu, Haining
    Xu, Haixia
    Peng, Ziyue
    Liu, Chun
    Li, Jianjun
    Wang, Chengqiang
    Xu, Tao
    Zhu, Lixin
    ACS APPLIED MATERIALS & INTERFACES, 2022, 14 (26) : 29506 - 29520
  • [22] Engineered bio-nanocomposite magnesium scaffold for bone tissue regeneration
    Parai, Rohan
    Bandyopadhyay-Ghosh, Sanchita
    JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2019, 96 : 45 - 52
  • [23] Incorporation of graphene oxide as a coupling agent in a 3D printed polylactic acid/hardystonite nanocomposite scaffold for bone tissue regeneration applications
    Tavakoli, Mohamadreza
    Emadi, Rahmatollah
    Salehi, Hossein
    Labbaf, Sheyda
    Varshosaz, Jaleh
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 253
  • [24] Effect of Bone Morphogenic Protein-2-Loaded Mesoporous Strontium Substitution Calcium Silicate/Recycled Fish Gelatin 3D Cell-Laden Scaffold for Bone Tissue Engineering
    Yu, Chun-Ta
    Wang, Fu-Ming
    Liu, Yen-Ting
    Ng, Hooi Yee
    Jhong, Yi-Rong
    Hung, Chih-Hung
    Chen, Yi-Wen
    PROCESSES, 2020, 8 (04)
  • [25] A tailored polylactic acid/polycaprolactone biodegradable and bioactive 3D porous scaffold containing gelatin nanofibers and Taurine for bone regeneration
    Samadian, Hadi
    Farzamfar, Saeed
    Vaez, Ahmad
    Ehterami, Arian
    Bit, Arindam
    Alam, Mostafa
    Goodarzi, Arash
    Darya, Gholamhossein
    Salehi, Majid
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [26] A tailored polylactic acid/polycaprolactone biodegradable and bioactive 3D porous scaffold containing gelatin nanofibers and Taurine for bone regeneration
    Hadi Samadian
    Saeed Farzamfar
    Ahmad Vaez
    Arian Ehterami
    Arindam Bit
    Mostafa Alam
    Arash Goodarzi
    Gholamhossein Darya
    Majid Salehi
    Scientific Reports, 10
  • [27] Electrospun biocompatible Gelatin- Chitosan/Polycaprolactone/Hydroxyapatite nanocomposite scaffold for bone tissue engineering
    Ahmadi, Samira Arab
    Pezeshki-Modaress, Mohamad
    Irani, Shiva
    Zandi, Mojgan
    INTERNATIONAL JOURNAL OF NANO DIMENSION, 2019, 10 (02) : 169 - 179
  • [28] Chitosan/MWCNTs nanocomposite coating on 3D printed scaffold of poly 3-hydroxybutyrate/magnetic mesoporous bioactive glass: A new approach for bone regeneration
    Azadani, Reyhaneh Nasr
    Karbasi, Saeed
    Poursamar, Ali
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 260
  • [29] Vascularized bone regeneration accelerated by 3D-printed nanosilicate-functionalized polycaprolactone scaffold
    Xu, Xiongcheng
    Xiao, Long
    Xu, Yanmei
    Zhuo, Jin
    Yang, Xue
    Li, Li
    Xiao, Nianqi
    Tao, Jing
    Zhong, Quan
    Li, Yanfen
    Chen, Yuling
    Du, Zhibin
    Luo, Kai
    REGENERATIVE BIOMATERIALS, 2021, 8 (06)
  • [30] Carboxymethyl carrageenan immobilized on 3D-printed polycaprolactone scaffold for the adsorption of calcium phosphate/strontium phosphate adapted to bone regeneration
    Ataie, Maryam
    Nourmohammadi, Jhamak
    Seyedjafari, Ehsan
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 206 : 861 - 874
12345