3D printed polycaprolactone/gelatin/ordered mesoporous calcium magnesium silicate nanocomposite scaffold for bone tissue regeneration

被引：0
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作者：
Mirzavandi, Zahra [1 ]
Poursamar, Seyed Ali [1 ]
Amiri, Farshad [1 ]
Bigham, Ashkan [2 ,3 ]
Rafienia, Mohammad [1 ,4 ]
机构：
[1] Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
[2] Institute of Polymers, Composites, and Biomaterials, National Research Council, Naples, Italy
[3] Department of Chemical, Materials and Production Engineering, University of Naples Federico II, Naples, Italy
[4] Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
来源：
Journal of Materials Science: Materials in Medicine | 2024年 / 35卷 / 01期
关键词：
Tissue engineering scaffolds are three-dimensional structures that provide an appropriate environment for cellular attachment; proliferation; and differentiation. Depending on their specific purpose; these scaffolds must possess distinct features; including appropriate mechanical properties; porosity; desired degradation rate; and cell compatibility. This investigation aimed to fabricate a new nanocomposite scaffold using a 3D printing technique composed of poly(Ε-caprolactone) (PCL)/Gelatin (GEL)/ordered mesoporous calcium-magnesium silicate (om-CMS) particles. Different weight ratios of om-CMS were added and optimized; and a series of scaffolds were constructed for comparison purposes; including PCL 50%/Gel 50%; PCL; 50%/Gel; 45%/om-CMS%5; and PCL 50%/Gel 40%/om-CMS%10. The optimized weight ratio of om-CMS was 10% without leaving behind negative effects on the filaments’ structure. The scaffolds’ physical and chemical properties were assessed using various techniques; and their degradation rate; bioactivity potential; cell viability; attachment; and ALP activity were evaluated in vitro. The results demonstrated that the PCL 50%/Gel 40%/om-CMS10% scaffold had promising potential for further studies in bone tissue regeneration. Graphical Abstract: (Figure presented.). © The Author(s) 2024;
D O I：
10.1007/s10856-024-06828-5
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