Relationship between apoptosis and taxol production of Taxus cuspidata cells in two-phase coupling culture

被引：0
|
作者：
Ge, Zhiqiang [1 ]
Li, Jingchuan [1 ]
Hu, Zongding [1 ]
Yuan, Yingjin [1 ]
机构：
[1] Dept. of Pharmaceut. Eng., Sch. of Chem. Eng. and Technol., Tianjin Univ., Beijing 300072, China
来源：
Huagong Xuebao/Journal of Chemical Industry and Engineering (China) | 2002年 / 53卷 / 10期
关键词：
Oleic acid - Production;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）];
学科分类号：
0836 ; 090102 ;
摘要：
The relationships between apoptosis and taxol production of Taxus cuspidata cells cultured in coupling medium composed of oleic acid, as organic phase, and improved B5 medium were studied. The results showed that there was parabolic relationship between total taxol content and apoptosis rate. The coupling culture method effectively promoted taxol releasing from inside to outer of the cells. The effect of taxol on apoptosis decreased to minimum because most of taxol deposited in oleic acid. Thereby, it was presumed that the occurrence of apoptosis could promote the production of taxol.
引用
收藏
页码：1066 / 1070
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