Mononuclear tetraamineplatinum(II) complexes: Synthesis, anticancer activity, DNA binding, and cellular uptake

被引：0
|
作者：
Robillard, Marc S. [1 ]
Jansen, Bart A. J. [1 ]
Lochner, Martin [2 ]
Geneste, Hervé [2 ]
Li, Yi [2 ]
Brouwer, Jaap [1 ]
Hesse, Manfred [2 ]
Reedijk, Jan [1 ]
机构：
[1] Leiden Institute of Chemistry, P.O. Box 9502, NL-2300 RA Leiden, Netherlands
[2] Organisch-chemisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
来源：
| 2001年 / Verlag Helvetica Chimica Acta AG卷 / 84期
关键词：
Amines - Complexation - DNA - Positive ions - Synthesis (chemical) - Toxicity - Tumors;
D O I：
10.1002/1522-2675(20011017)84:103.0.CO;2-Z
中图分类号：
学科分类号：
摘要：
The synthesis of three bis[(tert-butoxy)carbonyl]-protected (tetramine)dichloroplatinum complexes 2a-c of formula cis-[PtCl2(LL)] and of their cationic deprotected analogs 3a-c and their evaluation with respect to in vitro cytotoxicity, intramolecular stability, DNA binding, and cellular uptake is reported. The synthesis comprises the complexation of K2[PtCl4] with di-N-protected tetramines 1a-c to give 2a-c and subsequent acidolysis, yielding 3a-c. The cytotoxicity of the complexes is in direct relation to the length of the polyamine. Complexes 3a-c display a significant higher affinity for CT DNA as well as for cellular DNA in A2780 cells than cisplatin.
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