Laser melting deposited technology was applied using an internal laser coaxial-powder feeding way, and the heat source model of among light-powder-substrate interaction was built, which was used to simulate the single channel of laser melting deposited Inconel718 alloy under different process parameters. The simulation was used by dead-live unit method, via changing the unit material properties and restarting solver to finish the change of metal powder to solid. The results show that when the scanning speed is constant, with increasing laser power from 500 W to 1000 W, the molten pool increases gradually, the highest temperature of molten pool also increases from 2494 K to 3456 K, and the width and height of deposited single channel increase. When the laser power is constant, with increasing scanning speed from 5 mm/s to 15 mm/s, the highest temperature of molten pool decreases from 2494 K to 2047 K, meantime, the width and height of deposition single channel decrease. The simulation results are almost consistent with the experimental results, thus, the model has good reliability and important application value. © 2018, Science Press. All right reserved.