An overview of engineering microbial production of nicotinamide mononucleotide

被引：1
|
作者：
Li, Boting [1 ]
Meng, Xiangfeng [1 ]
Liu, Weifeng [1 ]
机构：
[1] Shandong Univ, Microbiol Technol Inst, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Peoples R China
来源：
JOURNAL OF BIOTECHNOLOGY | 2024年 / 396卷
关键词：
Nicotinamide mononucleotide; Metabolic engineering; Synthetic metabolism; NAD plus metabolism; DIPHOSPHOPYRIDINE NUCLEOTIDE; NAD(+); IDENTIFICATION; BIOSYNTHESIS; RIBOSIDE; SYNTHETASES; METABOLISM; ROUTE; FUNGI;
D O I：
10.1016/j.jbiotec.2024.10.014
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
As the human body gradually ages, the cellular level of NAD+ will decline, which has been found to be related to a variety of age-related diseases. As a precursor of NAD+, NMN is able to effectively promote the synthesis of NAD+ with no significant side effects. Microbial production of NMN holds the potential to lower the production cost and facilitate its wide application. In this review, based on the metabolic pathway of NAD+, we summarize recent advances of metabolic engineering strategies for NMN biosynthesis. An outlook for future optimization to improve NMN production is also discussed.
引用
收藏
页码：80 / 88
页数：9
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