Peripheral RAFT Polymerization on a Covalent Organic Polymer with Enhanced Aqueous Compatibility for Controlled Generation of Singlet Oxygen

被引：0
|
作者：
Lai, Haiwang [1 ,3 ]
Yan, Jieyu [1 ]
Liu, Shan [1 ]
Yang, Qizhi [1 ]
Xing, Feiyue [1 ,2 ]
Xiao, Pu [3 ]
机构：
[1] Department of Immunobiology, College of Life Science and Technology, Jinan University, 601 Huangpu West Avenue, Guangzhou,510632, China
[2] MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou,510632, China
[3] Research School of Chemistry, The Australian National University, Canberra,ACT,2601, Australia
来源：
Advanced Materials | 2020年 / 59卷 / 26期
关键词：
A covalent organic polymer (COP) is prepared by crosslinking the photosensitizer 4,4’,4’’,4’’’-(porphyrin- 5,10,15,20-tetrayl)tetraaniline (TAPP) with 4,4’-(anthracene- 9,10-diyl)dibenzoic acid (ADDA) via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/4-dimethylaminopyridine coupling. The COP is further modified with a hydrophilic polymer, poly(poly(ethylene glycol) methyl ether methacrylate) by grafting-from reversible-addition-fragmentation chain transfer (RAFT) polymerization to enhance its solubility in various solvents. The modified COP can bind singlet oxygen through the formation of endoperoxide byADDA upon the exposure to red light irradiation. Singlet oxygen can be then released via the photodynamic mechanism or the cycloreversion by endoperoxide when heated at 110 8C. These results open new possibilities for simultaneous generation of singlet oxygen by the photodynamic route and singlet oxygen carriers, demonstrating promise for treating hypoxic tumors. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim;
D O I：
10.1002/ANGE.202002446
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页码：10517 / 10521
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