Rhodium-Catalyzed Cyclization of Terminal and Internal Allenols: An Atom Economic and Highly Stereoselective Access Towards Tetrahydropyrans

被引：0
|
作者：
Schmidt, Johannes P. [1 ]
Breit, Bernhard [1 ]
机构：
[1] Institute for Organic Chemistry, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, Freiburg im Breisgau,79104, Germany
来源：
Advanced Materials | 2020年 / 59卷 / 52期
关键词：
Stereoselectivity;
D O I：
10.1002/ANGE.202009166
中图分类号：
学科分类号：
摘要：
A comprehensive study of a diastereoselective Rhcatalyzed cyclization of terminal and internal allenols is reported. The methodology allows the atom economic and highly syn-selective access to synthetically important 2,4-disubstituted and 2,4,6-trisubstituted tetrahydropyrans (THP). Furthermore, its utility and versatility are demonstrated by a great functional-group compatibility and the enantioselective total synthesis of (—)-centrolobine. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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页码：23691 / 23696
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