Syntheses and crystal structure of 1, 5-benzothiazepine derivatives containing pyrazole

Ten chalcones were synthesized by Aldol condensation reaction of acetophenone or para-substituted acetophenones with 1-phenyl-3-methyl-5-aryloxyl-pyrazol-4-aldehyde under the strong alkali condition, then chalcones reacted with 2-aminobenzenethiol in glacial acetic acid under refluxing to give a series of 1, 5-benzothiazepine which have potentially useful pharmacological properties. The compounds were confirmed by means of elemental analysis, IR spectrum, 1H NMR and X-ray single-crystal diffraction analysis. The crystal of compound 6c belongs to a monoclinic system, space group P2(1)/n with cell parameters a = 1.1793(2) nm, b = 1.1907(2) nm, c = 1.8726(4) nm, α = 90°, β = 104.71(3)°, γ = 90°, M = 522.04, V = 2.5432(9) nm3, Dc = 1.363 Mg/m3, Z = 4, F(000) = 1088.