Urinary Clearance of Cranberry Flavonol Glycosides in Humans

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机构：
[1] Wang, Yifei
[2] Singh, Ajay P.
[3] Nelson, Heather N.
[4] Kaiser, Amanda J.
[5] Reker, Nicolette C.
[6] Hooks, Tisha L.
[7] Wilson, Ted
[8] 1,Vorsa, Nicholi
来源：
Vorsa, Nicholi (vorsa@aesop.rutgers.edu) | 2016年 / American Chemical Society卷 / 64期
关键词：
Cranberry is reported to have health benefits; including prevention of urinary tract infections and other chronic diseases; due to the high content of polyphenols; including flavonols and flavan-3-ols. The aim of this study was to determine the clearance of flavonol glycosides and flavan-3-ols and/or their metabolites in human urine. Ten healthy women volunteers ingested 240 mL of cranberry juice containing flavonol glycosides. Urine samples were collected at 0; 90; 225; and 360 min postingestion. While flavan-3-ols were not detected; five flavonol glycosides common in cranberry were identified. Quercetin-3-galactoside; the most abundant cranberry flavonol; exhibited the highest peak urine concentration (Cmax) of 1315 pg/mg creatinine; followed by quercetin-3-rhamnoside; quercetin-3-arabinoside; myricetin-3-arabinoside; and myricetin-3-galactoside. Quercetin-3-arabinoside showed delayed clearance; Cmax at 237 min (Tmax); relative to other flavonols (90-151 min). Both aglycone and the conjugated sugar moiety structure mediate the flavonol's bioavailability. Interindividual variation for bioavailability and clearance is also apparent. Metabolites; e.g; glucoronides; were not detected. © 2016 American Chemical Society;
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