Selective Access to Secondary Amines by a Highly Controlled Reductive Mono-N-Alkylation of Primary Amines

被引：0
|
作者：
Kumpaty, Hephzibah J. [1 ]
Bhattacharyya, Sukanta [2 ]
Rehr, Erik W. [1 ]
Gonzalez, Amelia M. [1 ]
机构：
[1] Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, WI 53190, United States
[2] Argonaut Technologies, 1101 Chess Drive, Foster City, CA 94404, United States
来源：
Synthesis | 2003年 / 14期
关键词：
Alkylation; -; Amines; Reduction;
D O I：
10.1055/s-2003-41066
中图分类号：
学科分类号：
摘要：
A selective and direct access to secondary amines is reported by reductive mono-N-alkylation of primary amines in the presence of Ti(i-PrO)4 and NaBH4. Secondary amines are obtained exclusively from a set of carbonyl compounds and primary amines, demonstrating high chemoselectivity toward reductive mono-N-alkylation.
引用
收藏
页码：2206 / 2210
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