Self-organized thermo-responsive hydroxypropyl cellulose nanoparticles for curcumin delivery

被引：0
|
作者：
Bielska, Dorota [1 ]
Karewicz, Anna [1 ]
Kamin´ski, Kamil [1 ]
Kielkowicz, Izabela [1 ]
Lachowicz, Tomasz [1 ]
Szczubialka, Krzysztof [1 ]
Nowakowska, Maria [1 ]
机构：
[1] Bielska, Dorota
[2] Karewicz, Anna
[3] Kamiński, Kamil
[4] Kielkowicz, Izabela
[5] Lachowicz, Tomasz
[6] Szczubialka, Krzysztof
[7] Nowakowska, Maria
来源：
Karewicz, A. (karewicz@chemia.uj.edu.pl) | 1600年 / Elsevier Ltd卷 / 49期
关键词：
A tunable temperature-responsive nanoparticulate system based on the ionic modifications of hydroxypropyl cellulose (HPC) was obtained. Two derivatives of HPC were successfully obtained and characterized: cationic (modified with trimethylammonium groups) and anionic (modified with styrenesulfonate groups). Due to the polycation-polyanion interactions they spontaneously self-assemble into nanoparticles in water. The size and surface charge of the nanoparticles can be controlled by the polycation/polyanion ratio. The resulting structures are spherical with diameters in the range from 150 to 250 nm; as confirmed by AFM; SEM; and DLS measurements. The size of the nanospheres increases in elevated temperatures. A model compound; curcumin; known for its anti-cancer and anti-inflammatory properties; was effectively entrapped inside nanospheres. Its release profile was found to be temperature-dependent. © 2013 Elsevier Ltd. All rights reserved;
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页码：2485 / 2494
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