DNA sequencing using nanopores and kinetic proofreading

被引：0
|
作者：
Xinsheng Sean Ling
机构：
[1] DepartmentofPhysics,BrownUniversity
来源：
Quantitative Biology | 2020年 / 8卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q811.4 [生物信息论];
学科分类号：
0711 ; 0831 ;
摘要：
We discuss the feasibility of using a nanopore sandwich device to implement the principle of kinetic proofreading to discriminate incorrect hybridizing oligonucleotides on a target DNA or RNA. We propose a method of sequencing DNA or RNA using this approach. The design parameters for such a DNA sequencer are estimated from the HopfeldNinio theory of kinetic proofreading and Schr?dinger's frst-passage-time distribution function.
引用
收藏
页码：187 / 194
页数：8
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