Progress of biological characterization and mechanism of enzymatic degradation of microcystinase

被引：0
|
作者：
Pan Y. [1 ]
Wang H. [1 ]
Zhan H. [1 ]
Sun H. [1 ]
机构：
[1] School of Architectural and Surveying & Mapping Engineering, Jiangxi University of Science and Technology, Ganzhou, 341000, Jiangxi
来源：
Huagong Xuebao/CIESC Journal | 2020年 / 71卷 / 03期
关键词：
Biocatalysis; Enzyme; Microcystinase; Microcystins; Molecular biology;
D O I：
10.11949/0438-1157.20191008
中图分类号：
学科分类号：
摘要：
The microcystins (MCs) produced and released by cyanobacteria blooms are highly stable in the natural environment and are difficult to be effectively removed by traditional water treatment technologies, posing a serious threat to drinking water safety and ecosystems. Microbial biodegradation is an effective strategy where microbial metabolic potential can be harnessed for in-situ and ex-situ detoxification of MCs. At present, many studies have shown that some bacteria isolated from water bodies and sediments are capable of degrading MCs, which as an efficient and environmentally friendly strategy for MCs removal. The critical enzyme identified in bacterial strains is referred to as MlrA (also known as microcystinase), play a major role in the water body bioremediation process, responsible for catalyzing the first step reaction in the MCs biodegradation pathway. In this paper, based on evolutionary relationships of MlrA, reviews the characteristics of enzyme activity, molecular structure and catalytic mechanism of this enzyme. The further research subjects of MlrA were also proposed. This review could provide a reference for bioremediation of contaminated water environment. © All Right Reserved.
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页码：945 / 954
页数：9
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