Advances in Studies on Toxicity and Transformation of Zearalenone and Its Derivatives

被引：0
|
作者：
He Y. [1 ]
Li M. [1 ]
Liu Y. [1 ]
Guan E. [1 ]
Jin R. [1 ]
Wang R. [1 ]
Bian K. [1 ]
机构：
[1] College of Cereal and Food, Henan University of Technology, Zhengzhou
来源：
Shipin Kexue/Food Science | 2023年 / 44卷 / 15期
关键词：
mycotoxin; toxicity; transformation; zearalenone; zearalenone derivatives;
D O I：
10.7506/spkx1002-6630-20220823-278
中图分类号：
学科分类号：
摘要：
Zearalenone (ZEN) is a mycotoxin produced by the Fusarium species, which has various toxic effects. The chemical structures of ZEN and its derivatives are similar to that of estrogen. When ingested by animals or humans, ZEN and its derivatives can lead to disturbance of estrogen balance, thereby harming the reproductive system. Moreover, they can alter gene structure and consequently affect gene expression, and can even cause damage to the immune system, thus weakening the immune response. ZEN is transformed and metabolized into ZEN derivatives during food processing or after absorption by animals and plants, and its toxicity is altered due to structural and physicochemical changes. Studying the toxicity of ZEN and its derivatives as well as their transformation and metabolism in various organisms is important for ensuring food security and mycotoxin toxicity risk assessment. © 2023 Chinese Chamber of Commerce. All rights reserved.
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页码：289 / 297
页数：8
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