Effects of diphenhydramine exposure on reproduction of mature Japanese medaka (Oryzias latipes)

被引：0

作者：

Seki T. ^{[1
]}

Katsura M. ^{[2
]}

Yamasaki M. ^{[2
]}

Yamashita K. ^{[2
]}

Kokushi E. ^{[2
]}

Uno S. ^{[2
]}

机构：

[1] The United Graduate School of Agricultural Science, Kagoshima University, 50-20 Shimoarata 4-Chome, Kagoshima

[2] Education and Research Center for Marine Resources and Environment, Faculty of Fisheries, Kagoshima University, 50-20 Shimoarata 4-Chome, Kagoshima

来源：

Chemosphere | 2024年 / 358卷

基金：

日本学术振兴会;

关键词：

Antihistamine; Chronic effect; Cross-generation; Feeding behavior; Reproductive toxicity;

D O I：

10.1016/j.chemosphere.2024.142163

中图分类号：

学科分类号：

摘要：

Diphenhydramine (DPH) is an antihistamine drug. It has been frequently detected in the environment, because it is not completely degraded in wastewater treatment plants. Recent studies have shown the adverse effects of DPH exposure to various aquatic organisms; however, its chronic effects on fish have been poorly elucidated. In this study, several pairs of mature Japanese medaka (Oryzias latipes) were exposed to DPH for a long period to determine the effects of DPH exposure on the subsequent generations, number of spawned and fertilized eggs, expression of sex-related genes, feeding behavior, embryo development, hatching rate, malformations among the hatched larvae, and mortality rate. The number of spawned eggs significantly decreased, when the parent fish were continuously exposed to 31.6 μg/L DPH for over 46 days. DPH exposure also altered the feeding behavior of medaka individuals, and increased the larval mortality rate. The effects of DPH exposure to fish may occur to some extent in the actual aquatic environment, although the risk evaluations in the field are limited. © 2024 The Authors

引用

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