Effects of diphenhydramine exposure on reproduction of mature Japanese medaka (Oryzias latipes)

被引：0
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作者：
Seki, Tamaki [1 ]
Katsura, Motoaki [2 ]
Yamasaki, Masatoshi [2 ]
Yamashita, Kazuki [2 ]
Kokushi, Emiko [2 ]
Uno, Seiichi [2 ]
机构：
[1] The United Graduate School of Agricultural Science, Kagoshima University, 50-20 Shimoarata 4-Chome, Kagoshima,890-0056, Japan
[2] Education and Research Center for Marine Resources and Environment, Faculty of Fisheries, Kagoshima University, 50-20 Shimoarata 4-Chome, Kagoshima,890-0056, Japan
来源：
Chemosphere | 2024年 / 358卷
关键词：
Diphenhydramine (DPH) is an antihistamine drug. It has been frequently detected in the environment; because it is not completely degraded in wastewater treatment plants. Recent studies have shown the adverse effects of DPH exposure to various aquatic organisms; however; its chronic effects on fish have been poorly elucidated. In this study; several pairs of mature Japanese medaka (Oryzias latipes) were exposed to DPH for a long period to determine the effects of DPH exposure on the subsequent generations; number of spawned and fertilized eggs; expression of sex-related genes; feeding behavior; embryo development; hatching rate; malformations among the hatched larvae; and mortality rate. The number of spawned eggs significantly decreased; when the parent fish were continuously exposed to 31.6 μg/L DPH for over 46 days. DPH exposure also altered the feeding behavior of medaka individuals; and increased the larval mortality rate. The effects of DPH exposure to fish may occur to some extent in the actual aquatic environment; although the risk evaluations in the field are limited. © 2024 The Authors;
D O I：
10.1016/j.chemosphere.2024.142163
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