Fabrication of an Enzyme Membrane for Creatinine Detection and Its Application to an Extended-Gate FET-Based Biosensor

被引：0
|
作者：
Hiroshiba N. [1 ]
Makino K. [1 ]
Michibata R. [1 ]
Hirofuji Y. [1 ]
Koike K. [1 ]
机构：
[1] Osaka Institute of Technology, Nanomaterials Microdevices Research Center, 5-16-1, Asahi-ku Ohmiya, Osaka
来源：
IEEJ Transactions on Electronics, Information and Systems | 2023年 / 143卷 / 04期
关键词：
biosensor; creatinine; enzyme membrane; extended-gate FET; silk fibroin;
D O I：
10.1541/ieejeiss.143.498
中图分类号：
学科分类号：
摘要：
An extended-gate field effect transistor (EGFET) based creatinine sensor using an enzyme-containing silk-fibroin membrane successfully fabricated. In this experiment, we used creatinine deiminase as a detection enzyme for serum creatinine, which is known as a marker of chronic kidney disease. The fabricated biosensor showed excellent potentiometric response to creatinine over a wide range from 0.007-0.4 mg/mL in phosphate buffer solution, which can enable to measure creatinine concentration in blood plasma. © 2023 The Institute of Electrical Engineers of Japan.
引用
收藏
页码：498 / 503
页数：5
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