Isolation and identification of antiarthritic constituents from glycine tabacina and network pharmacology-based prediction of their protective mechanisms against rheumatoid arthritis

被引：0
|
作者：
Tu, Yanbei [1 ]
Wang, Kai [1 ]
Jia, Xuejing [2 ]
Tan, Lihua [1 ]
Han, Bing [1 ]
Zhang, Qingwen [1 ]
Li, Yanfang [3 ]
He, Chengwei [1 ]
机构：
[1] State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao,999078, China
[2] College of Food Science and Technology, Guangdong Ocean University, Zhanjiang,524088, China
[3] School of Chemical Engineering, Sichuan University, Chengdu,610065, China
来源：
Journal of Agricultural and Food Chemistry | 2020年 / 68卷 / 39期
关键词：
Glycine tabacina (Labill.) Benth is an edible medicinal herb for rheumatoid arthritis (RA) treatment in folk medicine. Current phytochemical research on this dried herb led to the isolation of eight new coumestans; named glytabastan A-H (1-8); and twenty-three known compounds 9−31. Their structures were elucidated using spectroscopic methods. The antiarthritic activities of all isolates were evaluated; and the results showed that coumestans 1−6 and 8−10 could inhibit arthritic inflammation in vitro; while coumestans 1; 2; 9; and 10 significantly blocked the osteoclastogenesis induced by receptor activator of nuclear factor (NF) κB ligand (RANKL). Moreover; network pharmacological analysis revealed that the anti-RA effect of G. tabacina involved multitargets; multipathways such as PI3K/Akt and MAPK signaling pathways; and various biological processes such as inflammatory response and cytokine-mediated signaling pathways. These results suggested that this species and its novel coumestans could serve as potential antiarthritic agents for functional food or medicinal use. © 2020 American Chemical Society;
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页码：10664 / 10677
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