Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase

被引：0
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作者：
Zhu, Wei [1 ]
Doubleday, Peter F. [2 ]
Butrin, Arseniy [3 ]
Weerawarna, Pathum M. [1 ]
Melani, Rafael D. [2 ]
Catlin, Daniel S. [3 ]
Dwight, Timothy A. [1 ]
Liu, Dali [3 ]
Kelleher, Neil L. [1 ,2 ]
Silverman, Richard B. [1 ,2 ,4 ]
机构：
[1] Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Center for Developmental Therapeutics, Northwestern University, Evanston,IL,60208, United States
[2] Department of Molecular Biosciences, Northwestern University, Evanston,IL,60208, United States
[3] Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago,IL,60660, United States
[4] Department of Pharmacology, Northwestern University, Chicago,IL,60611, United States
来源：
Journal of the American Chemical Society | 2021年 / 143卷 / 21期
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Enzymes;
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页码：8193 / 8207
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