Strategies for Articular Cartilage Repair and Regeneration

被引:0
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作者
Liu, Yanxi [1 ]
Shah, Karan M. [2 ]
Luo, Jian [1 ,3 ]
机构
[1] Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
[2] Department of Oncology and Metabolism, The Medical School, The University of Sheffield, Sheffield, United Kingdom
[3] Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Centre), Tongji University School of Medicine, Shanghai, China
关键词
Repair - Regenerative Medicine;
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摘要
Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis. Currently, clinical treatments have limited ability to repair, for they often result in the formation of mechanically inferior cartilage. In this review, we discuss the factors that affect cartilage homeostasis and function, and describe the emerging regenerative approaches that are informing the future treatment options. Copyright © 2021 Liu, Shah and Luo.
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