Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish

被引：0
|
作者：
Makarova, N. [1 ]
Kalaparthi, Vivek [1 ]
Wang, Andrew [1 ]
Williams, Chris [1 ]
Dokukin, M.E. [1 ,2 ]
Kaufman, Charles K. [3 ]
Zon, Leonard [4 ]
Sokolov, I. [1 ,5 ,6 ]
机构：
[1] Department of Mechanical Engineering, Tufts University, Medford,MA, United States
[2] Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russia
[3] Department of Medicine, Division of Oncology, Washington University, St. Louis,MO, United States
[4] Boston Children's Hospital, Boston,MA, United States
[5] Department of Biomedical Engineering, Tufts University, Medford,MA, United States
[6] Department of Physics, Tufts University, Medford,MA, United States
来源：
Journal of the Mechanical Behavior of Biomedical Materials | 2020年 / 107卷
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摘要：
Despite sharing oncogenetic mutations, only a small number of cells within a given tissue will undergo malignant transformation. Biochemical and physical factors responsible for this cancer-initiation process are not well understood. Here we study biophysical differences of pre-melanoma and melanoma cells in a BRAFV600E/P53 zebrafish model. The AFM indentation technique was used to study the cancer-initiating cells while the surrounding melanocytes were the control. We observed a statistically significant decrease in the modulus of elasticity (the effective Young's modulus) of cancer-initiating cells compared to the surrounding melanocytes. No significant differences in the pericellular coat surrounding cells were observed. These results contribute to a better understanding of the factors responsible for the initiation of cancer. © 2020
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