Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish

被引：0

作者：

Makarova, N. ^{[1
]}

Kalaparthi, Vivek ^{[1
]}

Wang, Andrew ^{[1
]}

Williams, Chris ^{[1
]}

Dokukin, M.E. ^{[1
,2
]}

Kaufman, Charles K. ^{[3
]}

Zon, Leonard ^{[4
]}

Sokolov, I. ^{[1
,5
,6
]}

机构：

[1] Department of Mechanical Engineering, Tufts University, Medford,MA, United States

[2] Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russia

[3] Department of Medicine, Division of Oncology, Washington University, St. Louis,MO, United States

[4] Boston Children's Hospital, Boston,MA, United States

[5] Department of Biomedical Engineering, Tufts University, Medford,MA, United States

[6] Department of Physics, Tufts University, Medford,MA, United States

来源：

Journal of the Mechanical Behavior of Biomedical Materials | 2020年 / 107卷

关键词：

Cells;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Despite sharing oncogenetic mutations, only a small number of cells within a given tissue will undergo malignant transformation. Biochemical and physical factors responsible for this cancer-initiation process are not well understood. Here we study biophysical differences of pre-melanoma and melanoma cells in a BRAFV600E/P53 zebrafish model. The AFM indentation technique was used to study the cancer-initiating cells while the surrounding melanocytes were the control. We observed a statistically significant decrease in the modulus of elasticity (the effective Young's modulus) of cancer-initiating cells compared to the surrounding melanocytes. No significant differences in the pericellular coat surrounding cells were observed. These results contribute to a better understanding of the factors responsible for the initiation of cancer. © 2020

引用

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