Optimal control for COVID-19 pandemic with quarantine and antiviral therapy

In the absence of a proper cure for the disease, the recent pandemic caused by COVID-19 has been focused on isolation strategies and government measures to control the disease, such as lockdown, media coverage, and improve public hygiene. Mathematical models can help when these intervention mechanisms find some optimal strategies for controlling the spread of such diseases. We propose a set of nonlinear dynamic systems with optimal strategy including practical measures to limit the spread of the virus and to diagnose and isolate infected people while maintaining consciousness for citizens. We have used Pontryagin's maximum principle and solved our system by the finite difference method. In the end, several numerical simulations have been executed to verify the proposed model using Matlab. Also, we pursued the resilience of the parameters of control of the nonlinear dynamic systems, so that we can easily handle the pandemic situation. © 2021 The Authors