In order to study the effects of thermal oxidative aging on the multiple damage healing properties of nano montmorillonite (MMT) asphalt, based on dynamic shear rheometer, scanning electron microscope, fourier transform infrared spectroscopy and gel permeation chromatography, the effects of multiple damage healing methods on the nano modified asphalt at different aging time were discussed, while the effects of asphalt micro morphology, chemical structure and molecular weight distribution on the healing properties were also studied. Results showed that the healing index of styrene-butadiene-styrene (SBS) modified asphalt decreases with the extension of aging time, while the influence of aging time on the healing performance of SBS modified asphalt increased with the increase of damage times. MMT could enhance the aging resistance performance of asphalt. The volatilization of light components in asphalt was inhibited in short term aging, while the number of molecular chains, length of branched chains and content of small molecules in asphalt were less affected by aging, thus slowing down the effect of aging on the healing performance of asphalt. However, with the extension of aging time, the layered MMT in asphalt was separated from the asphalt phase, while the aging resistance performance of MMT was effected. At this stage, nano modified asphalt basically lost healing ability under multiple damage. © 2022, Materials Review Magazine. All right reserved.