Bionics can create manmade system to replicate biosystem's behaviors or acts through designing and optimizing functional materials and smart devices. The environmental responsive hydrogels (ERHs) can discern and react to a variety of stimuli, and are flexible, wet, and biocompatible. Similar to biological soft tissue structure and composition, ERHs can be ideal interface materials for biomimetic devices. By forming asymmetric structures, the devices made of ERHs can intelligently respond to environmental stimuli according to the materials selection and structure design. By focusing on ERHs asymmetric bionic structures, this article reviews monolayer and bilayer structured devices, and their advanced fabrication technologies. Through modularized functions and structure designs, one can assemble and integrate asymmetric structures according to the product requirements, which are ideal for efficiently and flexibly developing multifunctional bionic smart devices that have great potential for commercialization. © 2022, Materials Review Magazine. All right reserved.